Coming soon
SNAP-8
10mg · Single vial · Lyophilized powder
- Dose
- 10mg
- Pack size
- Single vial
- Form
- Lyophilized powder
- Storage
- 2–8°C
In vitro laboratory research use only · Not for human or veterinary use · Batch documented · Third-party tested · Ships from Canada
§ Research
Research · SNAP-8
Overview
SNAP-8 is a synthetic, acetylated eight-residue analog of the N-terminal domain of SNAP-25 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2). It is an elongated variant of argireline, the related six-residue SNAP-25 mimetic, extended by two residues to increase its resemblance to the native protein segment. Developed for the cosmetic ingredient sector, it is used as a research compound in studies of SNARE complex assembly, neurotransmitter exocytosis, and in topical formulation studies of expression-line wrinkles.
Mechanism of action
Neurotransmitter release at the neuromuscular junction depends on assembly of the SNARE complex, formed by SNAP-25, syntaxin, and synaptobrevin (VAMP), which drives fusion of acetylcholine-containing vesicles with the presynaptic membrane. SNAP-8 is proposed to act as a competitive mimic of the SNAP-25 N-terminus, occupying binding positions within the complex and destabilizing its assembly. The resulting reduction in vesicle docking and exocytosis is reported to attenuate acetylcholine release and muscle contraction. The mechanism parallels the SNARE-directed action of botulinum neurotoxins but involves no proteolytic cleavage of SNAP-25 and is considered reversible. Its capacity to penetrate intact skin in sufficient amounts to reach nerve terminals remains an open question.
Key research findings
- 01
Developer-reported in vitro assays describe inhibition of SNARE complex formation and catecholamine release in chromaffin cell models.
- 02
A 2024 split-face clinical study characterized a dissolving microneedle patch containing the compound for periorbital wrinkle, skin hydration, and elasticity endpoints.
- 03
Analytical chemistry studies of the related six-residue analog describe stability and detection challenges relevant to this class of SNAP-25 mimics in cosmetic matrices.
- 04
Independent, peer-reviewed controlled studies of SNAP-8 as a single agent remain limited, with most data originating from developer or formulation studies.
Published references
Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities
Argireline: Needle-Free Botox as Analytical Challenge
The information above is derived from published preclinical and clinical research. It is provided for educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations.